The hedgehog signaling pathway plays a key role in growth and differentiation of chondrocytes. Could blocking this pathway curb joint damage and slow progression of osteoarthritis? Nature Reviews Rheumatology
The goal of this study was to identify alternative splice variants from cell surface receptor genes, and to determine whether the novel proteins encoded exert therapeutic activity in an in vivo model of arthritis. Arthritis Research & Therapy
Rapid-onset dyspnea on exertion is presented in a 42-year-old woman with limited cutaneous systemic sclerosis. What are the challenges of diagnosing pulmonary arterial hypertension in this patient? Nature Clinical Practice Rheumatology
Dynamic contrast-enhanced magnetic resonance imaging may prove helpful in distinguishing between psoriatic and rheumatoid arthritis. American Journal of Roentgenology
Ectopic lymphoid structures in the synovium of rheumatoid arthritis patients support ongoing production of autoantibodies that sustain the arthritis process, according to a report in the January issue of PLoS Medicine. Reuters Health Information
Tumor necrosis factor (TNF) blockers may help patients with rheumatoid arthritis (RA) maintain or increase their hours at work, investigators in Stockholm report in a new study. Reuters Health Information
